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重组抗体
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NLRP3 Recombinant Rabbit mAb

发布时间:2024-09-27 17:20:33人气:

分类:

重组抗体

说明书:

RMAB48867

100ul

Human, Mouse, Rat

WB

3572210476 1731215430

伊诺瓦(武汉)生物科技有限公司

Product Name:NLRP3 Recombinant Rabbit mAb
Cat No.:RMAB48867
Clonality:Monoclonal
Species Reactivity:Human, Mouse, Rat
Tested Applications:WB
Recommended Dilution:WB
Size:30ul 50ul 100uL
Format:Liquid
Source:Rabbit
Purification Method:Affinity Purification
Isotype:IgG
Conjugate:Un-conjugated
Storage:Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen:Recombinant protein of human NLRP3
Calculated Molecular Weight:118 kDa
Observed Molecular Weight:118 kDa
GenBank Accession Number:Q96P20
Gene ID (NCBI):114548
Synonyms:AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
Background:This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
Category:Primary Ab


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